Sunday, February 28, 2010

Week Seven

  • How sophisticated is our understanding of cancer?
In my opinion, our understanding of cancer is shallow and though many research is done and our understanding is improving, I think the fact that it is generally acknowledged as a disease that is extremely hard to conquer, makes our understanding of cancer more hard, because we are thinking it as such a phenomenon that is strange and hard to understand in the back of our heads.

  • How does a TCM approach to cancer differ?

The way TCM approaches cancer differs greatly. TCM sees cancer as a way the patient maintains to be alive. The cancer was formed inevitably according to the patients' life styles as the great effort to live under the circumstances.

  • Are our genes still being shaped by natural selection?

Yes. I saw on TV that certain tribes have eye vision that tops the ordinary human because they needed to for survival since they were relying their diet on hunted animals and needed the exceptionally good eye sight.


Broccoli preparation and health

Preparation Makes a Difference
Did you know that cutting the florets into smaller pieces and the stems into thin slices and letting them sit for 5 to 6 minutes before cooking will enhance their cancer protective properties? Cutting broccoli into smaller pieces breaks the cells and activates an enzyme called myrosinase. The myrosinase converts some of the sulfur-containing chemicals found in broccoli (call glucosinolates) into other sulfur containing chemicals (called isothiocyanates) which research has shown to contain cancer preventive properties not found in the glucosinolates . Studies have actually pinpointed specific mechanisms, like changes in cellular genetic processes, which are involved in increasing cancer protection.
Since myrosinase is specifically activated by ascorbic acid (vitamin C), sprinkling your sliced broccoli with a little lemon juice, an excellent source of vitamin C, before letting it sit may also help increase myrosinase activity. Once broccoli is heated, even if it is just lightly steamed, the myrosinase enzyme will become inactivated. For this reason, the slicing of broccoli 5-6 minutes before steaming will enable the enzyme to go to work and convert some of the sulfur-containing compounds prior to steaming.
Increase Assimilation of Nutrients
This may raise the question of whether it would not be preferable to let the broccoli sit and eat it raw allowing the enzymes to continue functioning. While, of course, this is an option, we prefer to recommend slightly cooking broccoli. Light cooking tends to soften fibrous materials aiding digestion and increasing the potential assimilation of nutrients.
One study has shown that although there may be more vitamin C in a stalk or florets of raw broccoli, we absorb the vitamin C a little better once the broccoli has been steamed or boiled. In a carefully controlled study, the availability of vitamin C from raw broccoli was compared to the availability from cooked broccoli, orange sections and orange juice. All foods forms of vitamin C showed equal bioavailability, except for the vitamin C from raw broccoli, which was less well absorbed.
Lightly Cooked
Of key importance is the definition of "lightly cooked". Lightly cooked broccoli has a bright green color and has not been steamed or boiled for more than 3-5 minutes. Overcooking any vegetable will decrease its nutritional value.
Broccoli and Your Thyroid
The same cancer-preventing compounds that slicing helps activate in broccoli (isothiocyanates) may decrease thyroid function under certain circumstances. The jury is still out, however, on exactly how this process works, or how problematic it is for everyday eating. However, to err on the safe side, individuals with pre-existing and untreated thyroid conditions might want to avoid eating broccoli. The consumption of steamed broccoli that has not been cut would logically lower isothiocyanate intake, but even in this case, intestinal bacteria could produce the isothiocyanates once the steamed broccoli reached their area of the intestine.
We recommend that individuals with thyroid problems talk with their healthcare providers about the best way to proceed in this circumstance. For all individuals with healthy thyroid function (except those allergic to broccoli, of course) we recommend incorporating this magnificent food into your healthy eating plan, raw or steamed!

Thursday, February 11, 2010

I always eat my brocolli


Broccoli Broccoli

Broccoli is a member of the cabbage family, and is closely related to cauliflower. Its cultivation originated in Italy. Broccolo, its Italian name, means "cabbage sprout." Because of its different components, broccoli provides a range of tastes and textures, from soft and flowery (the floret) to fibrous and crunchy (the stem and stalk). Do not let the smell of the sulfur compounds that are released while cooking keep you away from this highly nutritious vegetable.


This chart graphically details the %DV that a serving of Broccoli provides for each of the nutrients of which it is a good, very good, or excellent source according to our Food Rating System. Additional information about the amount of these nutrients provided by Broccoli can be found in the Food Rating System Chart. A link that takes you to the In-Depth Nutritional Profile for Broccoli, featuring information over 80 nutrients, can be found under the Food Rating System Chart.

Health Benefits

Protection against Cancer

Like other cruciferous vegetables, broccoli contains the phytonutrients sulforaphane and the indoles, which have significant anti-cancer effects. Research on indole-3-carbinol shows this compound helps deactivate a potent estrogen metabolite (4-hydroxyestrone) that promotes tumor growth, especially in estrogen-sensitive breast cells, while at the same time increasing the level of 2-hydroxyestrone, a form of estrogen that can be cancer-protective. Indole-3-carbinol has been shown to suppress not only breast tumor cell growth, but also cancer cell metastasis (the movement of cancerous cells to other parts of the body).

Scientists have found that sulforaphane boosts the body's detoxification enzymes, potentially by altering gene expression, thus helping to clear potentially carcinogenic substances more quickly. When researchers at Johns Hopkins studied the effect of sulphoraphane on tumor formation in lab animals, those animals given sulforaphane had fewer tumors, and the tumors they did develop grew more slowly and weighed less, meaning they were smaller.

A study published in the cancer journal, Oncology Report demonstrated that sulforaphane, which is a potent inducer of Phase 2 liver detoxification enzymes, also has a dose-dependent ability to induce cell growth arrest and cell death via apoptosis (the self-destruct sequence the body uses to eliminate abnormal cells) in both leukemia and melanoma cells.

Sulforaphane may also offer special protection to those with colon cancer-susceptible genes, suggests a study conducted at Rutgers University and published online in the journal Carcinogenesis.

In this study, researchers sought to learn whether sulforaphane could inhibit cancers arising from one's genetic makeup. Rutgers researchers Ernest Mario, Ah-Ng Tony Kong and colleagues used laboratory mice bred with a genetic mutation that switches off the tumor suppressor gene known as APC, the same gene that is inactivated in the majority of human colon cancers. Animals with this mutation spontaneously develop intestinal polyps, the precursors to colon cancer.

The study revealed that in animals fed sulforaphane, tumors were smaller, grew more slowly and had higher apoptotic (cell suicide) indices. Additionally, those fed a higher dose of sulforaphane had less risk of developing polyps than those fed a lower dose.

The researchers found that sulforaphane suppressed certain kinase enzymes. Kinases are cell signaling enzymes that are present not only in animals, but also in humans. The kinases suppressed by sulforaphane signal celluar activites that promote colon cancer.

According to lead researcher, Dr. Kong, "Our study corroborates the notion that sulforaphane has chemopreventive activity…Our research has substantiated the connection between diet and cancer prevention, and it is now clear that the expression of cancer-related genes can be influenced by chemopreventive compounds in the things we eat."

Another study, published in Cancer, the journal of the American Cancer Society, looked at indole-3-carbinol (I3C), a naturally occurring component of Brassica vegetables, such as broccoli, cabbage, and Brussels sprouts. I3C has been recognized as a promising anticancer agent against certain reproductive tumor cells. This laboratory study evaluated I3C's effects on cell cycling progression and cancer cell proliferation in human prostate cancer cells. I3C was shown to suppress the growth of prostate cancer cells in a dose-dependent manner by blocking several important steps in cell cycling and also to inhibit the production of prostate specific antigen (PSA), a protein produced by the prostate whose rising levels may indicate prostate cancer. Researchers noted that the results of this study demonstrate that "I3C has a potent antiproliferative effect" in human prostate cancer cells, which qualifies it as "a potential chemotherapeutic agent" against human prostate cancer.

New research has greatly advanced scientists' understanding of just how Brassica family vegetables such as broccoli, cabbage, cauliflower, kale and Brussels sprouts help prevent cancer. When these vegetables are cut, chewed or digested, a sulfur-containing compound called sinigrin is brought into contact with the enzyme myrosinase, resulting in the release of glucose and breakdown products, including highly reactive compounds called isothiocyanates.

Isothiocyanates are not only potent inducers of the liver's Phase II enzymes, which detoxify carcinogens, but research recently conducted at the Institute for Food Research in the U.K. shows one of these compounds, allyl isothicyanate, also inhibits mitosis (cell division) and stimulates apoptosis (programmed cell death) in human tumor cells.

Crucifers Cut Risk of Bladder Cancer

Human population as well as animal studies consistently show that diets high in cruciferous vegetables, such as broccoli, kale, cabbage and cauliflower, are associated with lower incidence of certain cancers, including lung, colon, breast and ovarian cancer. Now, research published in the International Journal of Cancer (Zhao H, Lin J) suggests that bladder cancer can join the list.

University of Texas researchers analyzed the diets of 697 newly diagnosed bladder cancer cases and 708 healthy controls matched by age, gender and ethnicity. Average daily intake of cruciferous vegetables was significantly lower in those with bladder cancer than in healthy controls.

Those eating the most cruciferous vegetables were found to have a 29% lower risk of bladder cancer compared to participants eating the least of this family of vegetables.

Crucifers' protective benefits were even more pronounced in three groups typically at higher risk for bladder cancer: men, smokers, and older individuals (aged at least 64).

Diagnosed in about 336,000 people every year worldwide, bladder cancer is three times more likely to affect men than women, according to the European School of Oncology.

Crucifers' well known cancer-fighting properties are thought to result from their high levels of active phytochemicals called glucosinolates, which our bodies metabolize into powerful anti-carcinogens called isothiocyanates.

Isothiocyanates offer the bladder, in particular, significant protection, most likely because the majority of compounds produced by isothiocyanate metabolism travel through the bladder en route to excretion in the urine, suggested the researchers.

Kaempferol-rich Broccoli Protective against Ovarian Cancer

A prospective study looking at dietary intake of 5 common flavonoids in 66,940 women in the Nurses Health Study over 18 years of follow up found those whose diets provided the most of 5 common flavonoids (myricetin, kaempferol, quercetin, and luteolin), had a 25% reduced risk of ovarian cancer, compared with those consuming the least.

Women whose diets provided the most kaempferol, a flavonoid concentrated in non-herbal tea (like green tea), broccoli and onions, were found to have a 40% lower risk of ovarian cancer, compared to women with the lowest kaempferol intake. Similarly, women whose diets provided the most luteolin intake had a 34% reduced risk of ovarian cancer, compared those with the lowest luteolin intake. Celery and parsley are some of the most highly concentrated sources of luteolin, which is also found in rutabagas, hot peppers and spinach. (Gates Ta, Tworoger SS, et al., Int J Cancer.)

Cruciferous Vegetables Help Lower Risk of Certain Aggressive Prostate Cancers

Researchers from Canada and the U.S. evaluated the association between prostate cancer risk and intake of fruits and vegetables in 29,361 men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. While there was no relationship found between overall prostate cancer risk and fruit and vegetable consumption, there was a relationship found between aggressive stage III and stage IV cancers that had expanded beyond the prostate gland (called extraprostatic prostate cancers) and vegetable intake. Consuming at least one weekly serving of cruciferous vegetables was associated with a near 40% reduction in risk of stage III and stage IV tumors risk, with broccoli and cauliflower offering the most protection. Men eating broccoli more than once a week were 45% less likely to develop stage III and IV prostate cancers, and eating cauliflower more than once a week conferred a 52% reduction in stage III and stage IV prostate cancer risk. (Kirsh VA, Peters U, et al., J Natl Cancer Inst.)

Broccoli Teams Up with Tomatoes to More Effectively Fight Prostate Cancer

Broccoli and tomatoes-two vegetables separately recognized for their cancer-fighting capabilities-are even more successful against prostate cancer when working as a team in the daily diet, shows a study published in Cancer Research.

"When tomatoes and broccoli are eaten together, we see an additive effect. We think it's because different bioactive compounds in each food work on different anti-cancer pathways," said John Erdman, Professor of Food Science and Human Nutrition at the University of Illinois.

Starting one month before male rats were implanted with prostate tumors, Erdman and doctoral candidate Kirstie Canene-Adams fed the animals one of 5 different diets. Then they compared the cancer-preventive effects of the diets to treatment with finasteride, a drug commonly prescribed for men with enlarged prostates, or surgical castration.

The diets contained one of the following: 10% tomato, 10% broccoli, 5% tomato plus 5% broccoli, 10% tomato plus 10% broccoli, or lycopene (23 or 224 nmol/g diet).

The tomato and broccoli given as powders made from the whole vegetable to compare the effects of eating the whole food to simply consuming one active compound as a nutritional supplement- in this case, lycopene, a carotenoid found in tomatoes.

After 22 weeks, when the rats' were sacrificed and their prostate tumors weighed, the 10% tomato/broccoli combination was shown to greatly outperform all other diets, shrinking prostate tumors by 52%.

Broccoli alone decreased tumor weight by 42%, and tomato alone by 34%.

Lycopene alone (23 or 224 nmol/g diet) came in last, reducing tumor weight by 7% and 18% respectively.

Only castration-a last resort option for most men, although it resulted in a 62% reduction in prostate tumor weight-approached the level of protection delivered by the tomato/broccoli diet. Said Erdman, "As nutritionists, it was very exciting to compare this drastic surgery to diet and see that tumor reduction was similar."

"Older men with slow-growing prostate cancer who have chosen watchful waiting over chemotherapy and radiation should seriously consider altering their diets to include more tomatoes and broccoli," said Canene-Adams.

To get the prostate health benefits seen in this study, a 55-year-old man would need to consume 1.4 cups of raw broccoli and 2.5 cups of fresh tomato, 1 cup of tomato sauce or ½ cup of tomato paste daily, said Canene-Adams.

Erdman noted that this study shows eating whole foods is better than taking isolated nutrients. "It's better to eat tomatoes than to take a lycopene supplement-and cooked tomatoes may be better than raw tomatoes. Chopping and heating make the cancer-fighting constituents of tomatoes and broccoli more bioavailable," he said.

Practical Tips: While the phytonutrients in tomatoes become more concentrated when they are cooked into a sauce or paste, and more bioavailable when eaten with a little oil, those in broccoli will be greatly reduced if this vegetable is overcooked. Steam or healthy sauté broccoli no more than 5 minutes.

Also, broccoli's cancer-preventive compounds form after it has been cut, but heat denatures the enzyme necessary for this process. For optimal nutrient formation, cut broccoli florets in half or into quarters, depending on their initial size, and let sit for 5 minutes before cooking.

Broccoli and tomatoes can make a delicious team at virtually any meal or snack:

  • Healthy sauté broccoli and onion, then add to your favorite breakfast omelet and serve with grilled tomatoes.
  • Enjoy a bowl of tomato soup along with a salad including broccoli florets for lunch.
  • Add lightly steamed broccoli florets to the tomato-paste toppings on your favorite pizza.
  • Healthy sauté broccoli florets along with other favorite vegetables, such as onions and mushrooms, add to pasta sauce and use to top whole wheat pasta or brown rice.
  • For a quick snack, serve raw broccoli florets along with the carrot and celery sticks, dip and crackers, and toast your prostate's health with a glass of tomato juice.

Optimize Your Cells' Detoxification / Cleansing Ability

For about 20 years, we've known that many phytonutrients work as antioxidants to disarm free radicals before they can damage DNA, cell membranes and fat-containing molecules such as cholesterol. Now, new research is revealing that phytonutrients in broccoli work at a much deeper level. These compounds actually signal our genes to increase production of enzymes involved in detoxification, the cleansing process through which our bodies eliminate harmful compounds.

The phytonutrients in broccoli and other cruciferous vegetables initiate an intricate dance inside our cells in which gene response elements direct and balance the steps among dozens of detoxification enzyme partners, each performing its own protective role in perfect balance with the other dancers. The natural synergy that results optimizes our cells' ability to disarm and clear free radicals and toxins, including potential carcinogens, which may be why cruciferous vegetables appear to significantly lower our risk of cancer.

Recent studies show that those eating the most cruciferous vegetables have a much lower risk of prostate, colorectal and lung cancer-even whencompared to those who regularly eat other vegetables:

In a study of over 1,000 men conducted at the Fred Hutchinson Cancer Research Center in Seattle, WA, those eating 28 servings of vegetables a week had a 35% lower risk of prostate cancer, but those consuming just 3 or more servings of cruciferous vegetables each week had a 44% lower prostate cancer risk.

In the Netherlands Cohort Study on Diet and Cancer, in which data was collected on over 100,000 people for more than 6 years, those eating the most vegetables benefited with a 25% lower risk of colorectal cancers, but those eating the most cruciferous vegetables did almost twice as well with a 49% drop in their colorectal cancer risk.

A study of Chinese women in Singapore, a city in which air pollution levels are often high putting stress on the detoxification capacity of residents' lungs, found that in non-smokers, eating cruciferous vegetables lowered risk of lung cancer by 30%. In smokers, regular cruciferous vegetable consumption reduced lung cancer risk an amazing 69%!

How many weekly servings of cruciferous vegetables do you need to lower your risk of cancer? Just 3 to 5 servings-less than one serving a day! (1 serving = 1 cup)

To get the most benefit from your cruciferous vegetables like broccoli, be sure to choose organically grown varieties (their phytonutrient levels are higher than conventionally grown), and steam lightly (this method of cooking has been shown to not only retain the most phytonutrients but to maximize their availability).

For a brief overview of the process through which cruciferous vegetables boost our ability to detoxify or cleanse harmful compounds and examples of how specific phytonutrients in crucifers work together to protect us against cancer, see our FAQ: Optimizing Your Cells' Detoxification/Cleansing Ability by Eating Cruciferous Vegetables.

Broccoli definitely proves the adage, "Good things come in small packages" since by weight they provide an even more concentrated source of sulfur-containing phytonutrients than mature broccoli. Researchers estimate that broccoli sprouts contain 10-100 times the power of mature broccoli to boost enzymes that detoxify potential carcinogens! A healthy serving of broccoli sprouts in your salad or sandwich can offer some great health benefits.

Support Stomach Health

A study published in Antimicrobial Agents and Chemotherapy provides support for broccoli's ability to eliminate Helicobacter pylori (H. pylori). In this study, sulforaphane, a phytonutrient richly abundant in the form of its precursor in broccoli and broccoli sprouts, was able to completely eradicate H. pylori in 8 of 11 laboratory animals that had been infected with the bacterium via the implantation of infected human gastric cells. Results were so dramatic the researchers concluded that sulforaphane-rich broccoli may be of benefit in the treatment or prevention of infection with H. pylori, a primary cause of ulcers. Clinical research is being planned that will hopefully confirm these findings and other similar findings, potentially offering people an effective dietary approach to eliminate H. pylori.

A more recent study published in Inflammopharmacology also supports these findings.

The research team, led by Akinori Yanaka of the University of Tsukuba, Japan, found that in patients with H. pylori infection, a diet including 100 grams of broccoli sprouts per day (about 3 ounces) resulted in a significant reduction of H. pylori and pepsinogen (a biomarker in the blood indicating the degree of gastritis).

The researchers think these beneficial results are due to broccoli sprouts' especially rich concentration of sulforaphane, which can protect against oxidative (free radical) damage in cells that can damage DNA, potentially causing cancer.

An H. pylori infection results in a constant barrage of oxidative damage to the cells that make up the lining of the stomach. Cells can survive against such chronic oxidative stress by increasing their protective arsenal of anti-oxidant enzymes, thereby protecting cells from DNA damage.

Recent studies have shown that the gene encoding Nrf-2 (NF-E2 p45-related factor-2) plays an important role in increasing the production of antioxidant enzymes protective against oxidative stress. Sulforaphane stimulates this nrf-2 gene-dependent production of anti-oxidant enzymes, thereby protecting cells from oxidative injury during H. pylori infection.

The Japanese team recruited 40 patients infected with H. pylori. Each day for two months, 20 patients ate a diet with 100 grams of sulforaphane-rich broccoli sprouts each day for two months, while the remaining 20 ate a diet with 100 grams of alfalfa sprouts instead.

"We wanted to test alfalfa spouts together with broccoli sprouts," Yanaka explained, "because the chemical constituents of the two plants are almost identical, except that 100 grams of broccoli sprouts contain 250 milligrams of sulforaphane glucosinolate whereas alfalfa sprouts contain neither sulforaphane nor sulforaphane glucosinolate."

(Glucosinolates, naturally occurring compounds in cruciferous vegetables such as broccoli, cauliflower and cabbage are enzymatically converted into sulforaphane and other bioactive components when the sprouts are chewed or cut.)

At the end of the two-month dietary regimen, patients consuming 100 grams of broccoli sprouts per day showed significantly less H. pylori and markedly decreased pepsinogen (an indicator of gastric atrophy). Those eating alfalfa sprouts did not show any effect.

"Even though we were unable to eradicate H. pylori, to be able suppress it and relieve the accompanying gastritis by means as simple as eating more broccoli sprouts is good news for the many people who are infected," said Yanaka. Infection with H. pylori is very common worldwide, and some experts estimate that nearly 50% of the American public is infected with the bacterium.

In addition, this research provides a deeper understanding of earlier studies suggesting broccoli sprouts have cancer-preventive properties. We now know that by increasing the production of anti-oxidant enzymes that protect against H. pylori-induced DNA damage, these sulforaphane-rich sprouts may also help prevent gastric cancer.

Help for Sun-Damaged Skin

Sulforaphane, an active compound found in Brassica family vegetables has already been shown to boost liver and skin cells' detoxifying abilities. Now, research conducted at John's Hopkins University and published in Cancer Letters indicates sulforaphane can help repair sun-damaged skin.

After exposure to a dose of UV light comparable to that which would be received by a person sunbathing by the sea on a clear summer's day, twice weekly for 20 weeks, test animals were treated with varying doses of broccoli extract applied topically to their backs, 5 days a week for 11 weeks. Broccoli extract counteracted the animals' skin cells' carcinogenic response to UV light.

Recent research has demonstrated that some sun exposure is essential for good health since it is needed for our production of vitamin D, yet tto much may be of concern as skin cancer rates continue to rise due to depletion of the ozone layer. Broccoli sprouts' ability to repair damage done to sun-exposed skin may offer us a way to receive the benefits of sunlight we need without increasing our risk for skin cancer.

A Cardio-Protective Vegetable

Broccoli has been singled out as one of the small number of vegetables and fruits that contributed to the significant reduction in heart disease risk seen in a recent meta-analysis of seven prospective studies. Of the more than 100,000 individuals who participated in these studies, those who diets most frequently included broccoli, tea, onions, and apples-the richest sources of flavonoids-gained a 20% reduction in their risk of heart disease.

Consumption of cruciferous vegetables, such as broccoli, is known to reduce the risk of a number of cancers, especially lung, colon, breast, ovarian and bladder cancer. Now, research reveals that crucifers provide significant cardiovascular benefits as well.

Researchers from the University of Hawaii have shown that, at the tiny concentration of just 100 micromoles per liter, a phytonutrient found in cruciferous vegetables, indole-3-carbinol, lowers liver cells' secretion of the cholesterol transporter, apolipoproteinB-100 by 56%! Apolipoprotein B-100 (apoB) is the main carrier of LDL cholesterol to tissues, and high levels have been linked to plaque formation in the blood vessels.

When liver cells were treated with I-3-C, not only was apoB-100 secretion cut by more than half, but significant decreases also occurred in the synthesis of lipids (fats), including triglycerides and cholesterol esters. (Maiyoh GK, Huh JE, et al., J Nutr.)

Cataract Prevention

Broccoli and other leafy green vegetables contain powerful phytonutrient antioxidants in the carotenoid family called lutein and zeaxanthin, both of which are concentrated in large quantities in the lens of the eye. When 36,000 men in the Health Professionals Follow-Up Study were monitored, those who ate broccoli more than twice a week had a 23% lower risk of cataracts compared to men who consumed this antioxidant-rich vegetable less than once a month. In addition to the antioxidant potential of broccoli's carotenoids, recent research has suggested that sulforaphane may also have antioxidant potential, being able to protect human eye cells from free radical stressors.

Stronger Bones with Broccoli

When it comes to building strong bones, broccoli's got it all for less. One cup of cooked broccoli contains 74 mg of calcium, plus 123 mg of vitamin C, which significantly improves calcium's absorption; all this for a total of only 44 calories. To put this in perspective, an orange contains no calcium, 69 mg of vitamin C, and 60-about 50% more-calories. Dairy products, long touted as the most reliable source of calcium, contain no vitamin C, but do contain saturated fat. A glass of 2% milk contains 121 calories, and 42 of those calories come from fat.

An Immune System Booster

Not only does a cup of broccoli contain the RDA for vitamin C, it also fortifies your immune system with a hefty 1359 mcg of beta-carotene, and small but useful amounts of zinc and selenium, two trace minerals that act as cofactors in numerous immune defensive actions.

A Birth Defect Fighter

Especially if you are pregnant, be sure to eat broccoli. A cup of broccoli supplies 94 mcg of folic acid, a B-vitamin essential for proper cellular division because it is necessary in DNA synthesis. Without folic acid, the fetus' nervous system cells do not divide properly. Deficiency of folic acid during pregnancy has been linked to several birth defects, including neural tube defects like spina bifida. Despite folic acid's wide occurence in food (it's name comes from the Latin word folium, meaning "foliage," because it's found in green leafy vegetables), folic acid deficiency is the most common vitamin deficiency in the world.

Description

Broccoli's name is derived from the Latin word brachium, which means branch or arm, a reflection of its tree-like shape that features a compact head of florets attached by small stems to a larger stalk. Because of its different components, this vegetable provides a complex of tastes and textures, ranging from soft and flowery (the florets) to fibrous and crunchy (the stem and stalk). Its color can range from deep sage to dark green to purplish-green, depending upon the variety. One of the most popular type of broccoli sold in North America is known as Italian green, or Calabrese, named after the Italian province of Calabria where it first grew.

Other vegetables related to broccoli are broccolini, a mix between broccoli and kale, and broccoflower, a cross between broccoli and cauliflower. Broccoli sprouts have also recently become popular as a result of research uncovering their high concentration of the anti-cancer phytonutrient, sulforaphane.

History

Broccoli has its roots in Italy. In ancient Roman times, it was developed from wild cabbage, a plant that more resembles collards than broccoli. It spread through out the Near East where it was appreciated for its edible flower heads and was subsequently brought back to Italy where it was further cultivated. Broccoli was introduced to the United States in colonial times, popularized by Italian immigrants who brought this prized vegetable with them to the New World.

How to Select and Store

Choose broccoli with floret clusters that are compact and not bruised. They should be uniformly colored, either dark green, sage or purple-green, depending upon variety, and with no yellowing. In addition, they should not have any yellow flowers blossoming through, as this is a sign of over maturity. The stalk and stems should be firm with no slimy spots appearing either there or on the florets. If leaves are attached, they should be vibrant in color and not wilted.

Broccoli is very perishable and should be stored in open plastic bag in the refrigerator crisper where it will keep for a week. Since water on the surface will encourage its degradation, do not wash the broccoli before refrigerating. Broccoli that has been blanched and then frozen can stay up to a year. Leftover cooked broccoli should be placed in tightly covered container and stored in the refrigerator where it will keep for a few days.

How to Enjoy

For some of our favorite recipes, click Recipes.

Tips for Preparing Broccoli:

Both cooked and raw broccoli make excellent additions to your meal plan. Some of the health-supporting compounds in broccoli can be increased by slicing or chewing, since both slicing and chewing can help activate enzymes in the broccoli. The heating (for example, steaming) of unsliced broccoli is also fine, since bacteria in the intestine also have enzymes that can cause production of health-supportive compounds. In fact, intake of cruciferous vegetables like broccoli may be able to shift the balance of enzymes in our gut such that we have increased numbers of gut bacteria with myrosinase enzymes! When cooking broccoli, however, the stems and florets should be prepared differently. Since the fibrous stems take longer to cook, they can be prepared separately for a few minutes before adding the florets. For quicker cooking, make lengthwise slits in the stems. While people do not generally eat the leaves, they are perfectly edible and contain concentrated amounts of nutrients.

The World's Healthiest Foods has long recommended quickly steaming or healthy sautéing as the best ways to cook vegetables to retain their nutrients. Several recent studies have confirmed this advice. The way you cook can dramatically impact the amount of nutrients your vegetables deliver.

A study published in the Journal of the Science of Food and Agriculture investigated the effects of various methods of cooking broccoli. Of all the methods of preparation, steaming caused the least loss of nutrients.

Microwaving broccoli resulted in a loss of 97%, 74% and 87% of its three major antioxidant compounds-flavonoids, sinapics and caffeoyl-quinic derivatives. In comparison, steaming broccoli resulted in a loss of only 11%, 0% and 8%, respectively, of the same antioxidants.

Study co-author, Dr. Cristina Garcia-Viguera, noted that "Most of the bioactive compounds are water-soluble; during heating, they leach in a high percentage into the cooking water. Because of this, it is recommended to cook vegetables in the minimum amount of water (as in steaming) in order to retain their nutritional benefits."

A second study, published in the same issue of the Journal of the Science of Food and Agriculture, provides similar evidence. In this study, Finnish researchers found that blanching vegetables prior to freezing caused losses of up to a third of their antioxidant content. Although slight further losses occurred during frozen storage, most bioactive compounds including antioxidants remained stable. The bottomline: how you prepare and cook your food may have a major impact on its nutrient-richness.

A third study, published in the British Medical Journal, checked to see how much of the B vitamin, folate, was retained after broccoli, spinach or potatoes were boiled or steamed.

Boiling for typical time periods caused a loss of 56% of the folate in broccoli, and 51% of the folate in spinach, while boiling potatoes caused only minimal folate loss. Steaming spinach or broccoli, in contrast, caused no significant loss of folate.

To this impressive knowledge base involving research on broccoli and its cooking methods has been added yet another important piece of information based on a study by researchers in the Department of Agriculture at Zhejiang University in Hangzhou, China. These researchers found steaming to be the only cooking method that could come close to raw broccoli in terms of vitamin C content, glucosinolate content, total carotenoid content, and chlorophyll content. In fact, they found no significant loss of nutrients in any of the categories when raw broccoli was steamed for a period of five minutes.

The take home message: Boiling potatoes may be okay, but to get the most benefit from cruciferous vegetables like broccoli, and greens like spinach, cook them lightly and rely on steaming as the optimal cooking method.

Further Confirmation Microwave Cooking Increases Nutrient Losses

Researchers set out to determine the effects of various approaches to microwave cooking (with differences in time cooked, power used, and use of water) on various health-promoting compounds found in broccoli (glucosinolates, phenolic compounds, minerals, and vitamin C). All microwave cooking conditions decreased levels of all the health-promoting compounds studied, except for mineral levels, which remained stable.

Vitamin C suffered the greatest reduction, which was determined to be due to degradation and leaching. Reductions in phenolic compounds and glucosinolates were found to be primarily due to leaching into water. Longer cooking times and higher volumes of water were determined to be the most problematic factors that contributed to loss of certain nutrients. (Lopez-Berenguer C, et al., J Agric Food Chem.) Practical Tip: If you plan on microwaving your broccoli, use the least amount of water possible and keep your cooking time as short as possible.

If You're Going to Stir Fry Your Broccoli, Use Extra Virgin Olive or Sunflower Oil

Broccoli is known to be a rich source of cancer-preventive glucosinolates, phenols, vitamin C and minerals (potassium, sodium, calcium, magnesium, iron, manganese, zinc, and copper). Stir-frying methods that would best maintain broccoli's rich array of nutrients were investigated by Spanish researchers.

When they stir-fried freshly harvested broccoli florets in various edible oils (extra virgin olive oil, refined olive oil, sunflower oil, peanut oil, soybean oil, and safflower oil), they discovered that levels of vitamin C and phenolic compounds were more affected than those of minerals and glucosinolates.

Only broccoli lightly stir-fried in extra virgin olive oil or sunflower oil retained similar glucosinolate and vitamin C levels as uncooked broccoli.

While we recommend cooking your broccoli by using either George's "Healthy Sauté" method (in which a few tablespoons of broth are used during cooking instead of oil, and the vegetable dressed with oil immediately afterwards), or light steaming, if you must use oil, select an organic extra virgin olive oil or sunflower oil, and be sure to stir fry for the shortest amount of time. (Moreno DA, Lopez-Berenguer C, et al., J Food Sci.)

A Few Quick Serving Ideas:

Sprinkle lemon juice and sesame seeds over lightly steamed broccoli.

Toss pasta with olive oil, pine nuts and healthy sautéed broccoli florets. Add salt and pepper to taste.

Purée cooked broccoli and cauliflower, then combine with seasonings of your choice to make a simple, yet delicious, soup.

Add broccoli florets and chopped stalks to omelets.

Individual Concerns

Broccoli is not a commonly allergenic food and is not known to contain measurable amounts of oxalates or purines.

Nutritional Profile

Broccoli contains glucosinolates, phytochemicals which break down to compounds called indoles and isothiocyanates (such as sulphoraphane). Broccoli also contains the carotenoid, lutein. Broccoli is an excellent source of the vitamins K, C, and A, as well as folate and fiber. Broccoli is a very good source of phosphorus, potassium, magnesium and the vitamins B6 and E.

For an in-depth nutritional profile click here: Broccoli.

In-Depth Nutritional Profile

In addition to the nutrients highlighted in our ratings chart, an in-depth nutritional profile for Broccoli is also available. This profile includes information on a full array of nutrients, including carbohydrates, sugar, soluble and insoluble fiber, sodium, vitamins, minerals, fatty acids, amino acids and more.

Introduction to Food Rating System Chart

In order to better help you identify foods that feature a high concentration of nutrients for the calories they contain, we created a Food Rating System. This system allows us to highlight the foods that are especially rich in particular nutrients. The following chart shows the nutrients for which this food is either an excellent, very good, or good source (below the chart you will find a table that explains these qualifications). If a nutrient is not listed in the chart, it does not necessarily mean that the food doesn't contain it. It simply means that the nutrient is not provided in a sufficient amount or concentration to meet our rating criteria. (To view this food's in-depth nutritional profile that includes values for dozens of nutrients - not just the ones rated as excellent, very good, or good - please use the link below the chart.) To read this chart accurately, you'll need to glance up in the top left corner where you will find the name of the food and the serving size we used to calculate the food's nutrient composition. This serving size will tell you how much of the food you need to eat to obtain the amount of nutrients found in the chart. Now, returning to the chart itself, you can look next to the nutrient name in order to find the nutrient amount it offers, the percent Daily Value (DV%) that this amount represents, the nutrient density that we calculated for this food and nutrient, and the rating we established in our rating system. For most of our nutrient ratings, we adopted the government standards for food labeling that are found in the U.S. Food and Drug Administration's "Reference Values for Nutrition Labeling." Read more background information and details of our rating system.

Broccoli, steamed
1.00 cup
156.00 grams
43.68 calories
Nutrient Amount DV
(%)
Nutrient
Density
World's Healthiest
Foods Rating
vitamin C 123.40 mg 205.7 84.8 excellent
vitamin K 155.20 mcg 194.0 79.9 excellent
vitamin A 2280.72 IU 45.6 18.8 excellent
folate 93.91 mcg 23.5 9.7 excellent
dietary fiber 4.68 g 18.7 7.7 excellent
manganese 0.34 mg 17.0 7.0 very good
tryptophan 0.05 g 15.6 6.4 very good
potassium 505.44 mg 14.4 6.0 very good
vitamin B6 (pyridoxine) 0.22 mg 11.0 4.5 very good
vitamin B2 (riboflavin) 0.18 mg 10.6 4.4 very good
phosphorus 102.80 mg 10.3 4.2 very good
magnesium 39.00 mg 9.8 4.0 very good
protein 4.66 g 9.3 3.8 very good
omega 3 fatty acids 0.20 g 8.3 3.4 very good
vitamin B5 (pantothenic acid) 0.79 mg 7.9 3.3 good
iron 1.37 mg 7.6 3.1 good
calcium 74.72 mg 7.5 3.1 good
vitamin B1 (thiamin) 0.09 mg 6.0 2.5 good
vitamin B3 (niacin) 0.94 mg 4.7 1.9 good
zinc 0.62 mg 4.1 1.7 good
vitamin E 0.75 mg 3.8 1.5 good
World's Healthiest
Foods Rating
Rule
excellent DV>=75% OR Density>=7.6 AND DV>=10%
very good DV>=50% OR Density>=3.4 AND DV>=5%
good DV>=25% OR Density>=1.5 AND DV>=2.5%

The chicken or the egg ?



The egg. The chicken was an embryo in the egg and that was the way the first chicken would be brought in life in the first place.

Can diversification save species ?


I think diversification can save species. The obsession for pure breeds ( which I understand people tend to have - including the one I have) would loathe or be sad to lose the pure breed of species but however, to at least preserve and protect the species we have I believe diversification is crucial. The way they do it, the manipulation of nature is quite discomforting to me too, and can of course bring many problems too. However, there is not good enough reason to ban the agriculture and aquaculture from diversifying the species.

Saturday, February 6, 2010

Classification of great apes

The Hominidae (anglicized hominids, also known as great apes) form a taxonomic family. including four extant genera : chimpanzees, gorillas, humans, and orangutans.
A number of known extinct genera are grouped with humans in the
Hominina subtribe, others with orangutans in the Ponginae subtribe. The most recent common ancestor of the Hominidae lived roughly 14 million years ago, when the ancestors of the orangutans speciated from the ancestors of the other three genera. The ancestors of the Hominidae family had already speciated from those of the Hylobatidae family, perhaps 15-20 million years ago.

On July 19, 2001, a 7-million-year-old
fossil skull, nicknamed "Toumaï" by its discoverers, and formally classified as Sahelanthropus tchadensis, was discovered in Chad. It is possibly the earliest hominine fossil ever found. In addition to its age, Toumaï, unlike the three- to four-million-year younger gracile australopithecine dubbed "Lucy", has a relatively flat face without the prominent snout seen on other pre-Homo hominids. Some researchers have made the suggestion that this previously unknown species may in fact be a direct ancestor of modern humans (or at least closely related to a direct ancestor). Others contend that one fossil is not enough to make such a claim because it would overturn the conclusions of over 100 years of anthropological study. A report on this finding was published in the journal Nature on July 11, 2002. While some scientists claim that it is merely the skull of a female gorilla ancestor, others have called it the most important hominine fossil since Australopithecus.

Orangutan
Some experts use evidence from the genome in addition to the Toumaï fossil to argue that the species associated with the split between chimpanzees and proto-humans interbred over a long period of time, swapping genes, before making a final separation. A paper, whose authors include
David Reich and Eric Lander (Harvard and MIT), was published in the journal Nature in May 2006.
It is generally believed that the Pan/Homo split occurred about 6.5 – 7.4 million years ago, but the
molecular clock (a method of calculating evolution based on the rate at which genes mutate) suggests the genera split 5.4 – 6.3 million years ago. Previous studies looked at average genetic differences between human and chimp. The new study compares the ages of key sequences of genes of modern humans and modern chimps. Some sequences are younger than others, indicating that chimps and humans gradually split apart over a period of 4 million years. The youngest human chromosome is the X chromosome which is about 1.2 million years more recent than the 22 autosomes.The X sex chromosome is known to be vulnerable to selective pressure. Its age suggests there was an initial split between the two species, followed by gradual divergence and interbreeding that resulted in younger genes, and then a final separation.
An alternative minority viewpoint is that Homo diverged from a common ancestor with Pongo perhaps as early as 13 million years ago while Pan is more closely related to Gorilla. This alternative is supported by characteristics uniquely shared between humans and orangutans such as dental structure, thick enamel, shoulder blade structure, thick posterior palate, single incisive foramen, high estriol production, and beard and mustache. There are at least 28 well corroborated such features compared with perhaps as little as one unique feature shared between humans and chimpanzees. It is widely believed that these physical features are misleading, but an alternative possibility is that orangutans have undergone more genetic change than humans and African apes have since their split from the common ancestor. If this had happened, then the apparent genetic similarity between humans and chimpanzees would not necessarily be due to a close evolutionary relationship.This theory has been proposed as an explanation as to why early hominids such as the australopiths not only look more like orangutans than either African ape, but also share characters unique to orangutans and their close fossil relatives such as a thickened posteror palate and anterior zygomatic roots.

Taxonomic history

Humans are one of the four extant hominid genera
The classification of the great apes has been
revised several times in the last few decades. Originally, the group was restricted to humans and their extinct relatives, with the other great apes being placed in a separate family, the Pongidae. This definition is still used by many anthropologists and by lay persons. However, that definition makes Pongidae paraphyletic because at least one great ape species appears to be more closely related to humans than other great apes. Most taxonomists nowadays encourage monophyletic groups so this would require the use of Pongidae to be restricted to one of the great ape groups only. Thus many biologists consider Hominidae to include Pongidae as the subfamily Ponginae, or restrict the latter to the orangutans and their extinct relatives like Gigantopithecus. The taxonomy shown here follows the monophyletic groupings according to the two theories of human and great ape relationships.
Especially close human relatives form a
subfamily, the Homininae. Some researchers go so far as to include chimpanzees and gorillas in the genus Homo along with humans, but it is more commonly accepted to describe the relationships as shown here. Alternatively, those fossil relatives that are more closely related to humans than the nearest living great ape species represent members of Hominidae without necessarily assigning subfamily or tribal categories. If the orangutan is the closest living relative of humans, there would be a sister group relationship between Hominidae and Pongidae, with the African apes comprising a separate family (Panidae) according to the morphological evidence.
Many extinct hominids have been studied to help understand the relationship between modern humans and the other extant hominids. Some of the extinct members of this family (as defined to encompass humans and chimpanzees) include Gigantopithecus,
Orrorin, Ardipithecus, Kenyanthropus, and the australopithecines Australopithecus and Paranthropus. In the orangutan model of human origin the Hominidae would include the australopiths, and possibly Orrorin and Kenyanthropus, but not Ardipithecus and Sahelanthropus that lack features necessary to provide strong corroboration as hominids.
The exact criteria for membership in the Homininae under the chimpanzee theory of human origins are not clear, but the subfamily generally includes those
species that share more than 97% of their DNA with the modern human genome, and exhibit a capacity for language or for simple cultures beyond the family or band. The theory of mind including such faculties as mental state attribution, empathy and even empathetic deception is a controversial criterion distinguishing the adult human alone among the hominids. Humans acquire this capacity at about four and a half years of age, whereas it has neither been proven nor disproven that gorillas and chimpanzees develop a theory of mind. This is also the case for some New World monkeys outside the family of great apes, as, for example, the capuchin monkeys.
However, without the ability to test whether early members of the Homininae (such as
Homo erectus, Homo neanderthalensis, or even the australopithecines) had a theory of mind, it is difficult to ignore similarities seen in their living cousins. Orangutans have also been shown to have culture comparable to that of chimpanzees and some say that the orangutan may also satisfy these criteria. These scientific debates take on political significance for advocates of Great Ape personhood.

Classification

Hominoid family tree

Skulls of an orangutan and a gorilla
The seven living species of great ape are classified in four
genera. The following classification is commonly accepted:
Family Hominidae: humans and other great apes; extinct genera and species excluded.
Subfamily
Ponginae
Genus
Pongo
Bornean Orangutan, Pongo pygmaeus
Pongo pygmaeus pygmaeus
Pongo pygmaeus morio
Pongo pygmaeus wurmbii
Sumatran Orangutan, Pongo abelii
Subfamily
Homininae
Tribe
Gorillini
Genus
Gorilla
Western Gorilla, Gorilla gorilla
Western Lowland Gorilla, Gorilla gorilla gorilla
Cross River Gorilla, Gorilla gorilla diehli
Eastern Gorilla, Gorilla beringei
Mountain Gorilla, Gorilla beringei beringei
Eastern Lowland Gorilla, Gorilla beringei graueri
Tribe
Hominini
Genus
Pan
Common Chimpanzee, Pan troglodytes
Central Chimpanzee, Pan troglodytes troglodytes
West African Chimpanzee, Pan troglodytes verus
Nigerian Chimpanzee, Pan troglodytes vellerosus
Eastern Chimpanzee, Pan troglodytes schweinfurthii
Bonobo (Pygmy Chimpanzee), Pan paniscus
Genus
Homo
Human, Homo sapiens sapiens
In addition to the extant species and subspecies above,
archaeologists, paleontologists, and anthropologists have discovered numerous extinct great ape species. The list below are some of the genera of those discoveries.
Subfamily
Ponginae (or Pongidae)
Gigantopithecus
Sivapithecus
Lufengpithecus
Ankarapithecus
Ouranopithecus
Subfamily
Homininae (or Hominidae)
Homo – immediate ancestors of modern humans
Homo habilis
Homo rudolfensis
Homo ergaster
Homo georgicus
Homo erectus
Homo cepranensis
Homo antecessor
Homo heidelbergensis
Homo rhodesiensis
Homo neanderthalensis
Homo sapiens
Homo sapiens idaltu
Archaic Homo sapiens (Cro-magnon)†
Homo floresiensis
Oreopithecus
Paranthropus
Australopithecus
Sahelanthropus†(hominid status highly problematic)
Orrorin
Ardipithecus
Kenyanthropus

Physical description
The great apes are large, tailless primates, with the smallest living species being the
Bonobo at 30 – 40 kilograms in weight, and the largest being the gorillas, with males weighing 140 – 180 kilograms. In all great apes, the males are, on average, larger and stronger than the females, although the degree of sexual dimorphism varies greatly among species. Although most living species are predominantly quadrupedal, they are all able to use their hands for gathering food or nesting materials, and, in some cases, for tool use.
Most species are
omnivorous, but fruit is the preferred food among all but humans. Chimpanzees and orangutans primarily eat fruit. When gorillas run short of fruit at certain times of the year or in certain regions, they resort to eating shoots and leaves, often of bamboo, a type of grass. Gorillas have extreme adaptations for chewing and digesting such low-quality forage, but they still prefer fruit when it is available, often going miles out of their way to find especially preferred fruits. In contrast, humans consume a large proportion of highly processed, low fiber foods, unusual proportions of grains (only very recently) and vertebrate flesh, as well as a wide variety of other foodstuffs. The teeth are similar to those of the Old World monkeys and gibbons, although they are especially large in gorillas. The dental formula is: Human teeth and jaws are markedly smaller for their size than those of other apes. Some scholars have speculated that humans' small teeth and jaws are adaptations to eating cooked food for more than a million years, but this idea remains controversial.

Gorilla
Gestation in great apes lasts 8–9 months, and results in the birth of a single offspring, or, rarely, twins. The young are born helpless, and the mother must care for them for long periods of time. Compared with most other mammals, great apes have a remarkably long adolescence, not being weaned for several years, and not becoming fully mature for 8–13 years in most species (longer in humans). As a result, females typically give birth only once every few years. There is no distinct breeding season.
Gorillas and chimpanzees live in family groups of around five to ten individuals, although much larger groups are sometimes noted. Chimpanzees live in larger groups that break up into smaller groups when fruit becomes less available. When small groups of female chimpanzees go off in separate directions to forage for fruit, the dominant male(s) can no longer control them and the females often mate with other subordinate males, whether by choice or not. In contrast, groups of gorillas stay together regardless of the availability of fruit. When fruit is hard to find, they resort to eating leaves and shoots. Because gorilla groups stay together, the male is able to monopolize the females in his group. This fact is related to gorillas' greater sexual dimorphism than chimpanzees'. In both chimpanzees and gorillas, the groups include at least one dominant male, and females leave the group at maturity. By contrast, orangutans are generally solitary. The social structure of humans is complex and highly variable. DNA studies suggest that, as in other apes, female humans are the sex that leaves the group at maturity, or at least has done so over evolutionary time.

Legal status
Due to the close genetic relationship between humans and other great apes, certain
animal rights organizations, such as the Great Ape Project, argue that non-human great apes are persons and should be given basic human rights. Some countries have instituted a research ban to protect great apes from any kind of scientific testing.
On 25 June 2008, the Spanish parliament supported a new law that would make "keeping apes for circuses, television commercials or filming" illegal.

Hominid Family Tree


It is just amazing how diverse branches the Hominid Family Tree has !

Reading This Evolutionary Tree:1. Dashed lines show how related species diverged from each other through a common ancestor.2. Faded lines indicate very unclear origin or descent.3. Branch points are called nodes. Nodes indicate a species that once lived, and was the common ancestor of two or more descendants.4. Horizontal lines indicate time.5. Orange vertical bars indicate how long a species is known, from fossils, to have existed.Common Misconceptions:
All species on this evolutionary tree are ancestors of Homo sapiens. This is not true. You can follow the dashed lines back through time to learn which species are proposed ancestors.
Evolution progresses toward a goal. Evolution does not necessarily follow from simple to more complex, or non-human to human.
Evolutionary trees are fixed. Evolutionary trees are not fixed. They are based on interpretations of current data. New evidence or new ways of interpreting existing evidence can revise them.

Is there a drug around for just about everything?

There is a drug around for just about everything or at least something to aver it can help and if there isn't the Pharmaceutical industry would find a way making it. We are living in an era that drugs dominate our everything and making drugs for almost just about everything for drug marketing that increases patient and doctor's urge and demand more and more on the consumer's end and of course there is a provider to meet the market's other end. Below is a CNN health article that talks about it.
You can't open a newsmagazine these days without finding pages of glitzy ads for prescription drugs. Drug marketing directly to consumers has exploded over the past few years: A reported $1.3 billion was spent on such advertising in 1998, more than double the amount spent in 1996. This may seem logical for a culture that has come to expect overstated claims for products and advertising pitches that rely on sex appeal, but for some it is going too far. Should prescription drugs be marketed like cars, beer and shampoo? Or are they a special kind of product that demands special treatment in the marketplace?
Pharmaceutical advertising combines medical information for the lay public with images of a healthy and carefree lifestyle. There are photos of smiling, vital people and colorful hot air balloons, along with pages of text -- both basic information in normal-sized type as well as paragraphs of medical indications, side effects and disclaimers in microtype.
The information in these ads does a service in addition to encouraging patients to ask doctors about specific drugs. It educates consumers about the latest developments in drugs for particular illnesses and provides information about what patients can expect when receiving certain treatments. This information must be accurate to do its job, however; and the federal Food and Drug Administration (FDA) has been reprimanding drug companies for creating ads with misleading and even false information.
The FDA continually identifies violations of federal drug advertising rules, citing everything from benefits yet to be proven for a drug for osteoporosis to contraceptive ads that "virtually ensure that consumers will have trouble fully comprehending any of the information." Can doctors keep up?
Besides needing to stay as informed as their patients about the latest drugs, doctors must now untangle whatever misconceptions are created by ads or convince a patient that a newly released drug is not the panacea it's claimed to be. Patient education is certainly part of what physicians ought to do, but it is already difficult in an era of shortened patient encounters without the need to undo what Madison Avenue has worked so hard to accomplish. Created demand meets constrained costs
There is significant pressure on drug companies to promote their products, particularly new drugs that have been brought to market after expensive research and development. These drugs need patients to take them and health plans to pay for them, and the combination is bound to create tension, especially as prescription drugs become the focus of continued increases in health care costs. It used to be that physician expertise was about all that decided how drugs were prescribed, and so drug companies would do what they could to influence a physician's mind. But now better informed and more demanding consumers ask for specific drugs and may refuse to accept generic substitutes. As managed care organizations implement drug formularies that restrict what can be prescribed, both physician and patient demands will be increasingly harder to satisfy.

Can we raise our levels of dopamine ourselves?

Dopamine, a neurotransmitter that stimulates the heart, controls movement, generates energy for metabolism, helps regulate the flow of information throughout the brain and allows us to experience feelings of pleasure can be raised by regular exercise and meditation. Certain foods have been found to regulate the production of dopamine enabling access to additional energy supplies and giving us the ability to respond more effectively emotionally and physically. Below is the description of them. In addition at the end I added an article about the inside look of Dopamine.

Proteins
Protein consumption is paramount for the regulation of the neurotransmitters in the brain due to their high amino acid content. Choose fish, eggs, chicken, turkey and red meat, suggests the Blessed Maine Herbs website. Fish has easily digestible protein, is low in calories and provides Omega 3 fatty acids, which may also help to stimulate the production of dopamine, according to MedHelp.com. Additionally, legumes, especially lima beans and fermented soy products like tempeh and miso are excellent sources of proteins. Dairy products like cheese and milk are also high in amino acids and help raise dopamine levels.

Beverages
Dopamine production and regulation is dependent on a variety of triggers, vitamin B6 being one, according to MedHelp.com. Drink watermelon juice, which is high in B6. It's a great fat-free addition to your diet and makes an excellent cleanser to remove toxins and wastes.

Wheat Germ
Wheat germ is high in phenylalanine, according to MedHelp.com, an essential amino acid that is converted to tyrosine, which helps to regulate the neurotransmitters and dopamine in particular. Sprinkle wheat germ over salads or on cereals for a nutty flavor addition to foods.

Nuts and Seeds
Raw almonds or pumpkin seeds make a great snack and help to regulate dopamine levels. Add sesame seeds to the list and sprinkle some on salads. Tahini is a paste made from sesame seeds, similar to peanut butter, and remember almond butter. Edgar Cayce, in his book, "Nourishing the Body Temple: Edgar Cayce's Approach to Nutrition, " states that a handful of raw almonds every day can prevent almost every disease known to man and increase health tenfold.

Herbs
A variety of herbs are known to help regulate dopamine levels, according to The Blessed Maine Herbs website, including nettles fenugreek, milk thistle, ginseng, peppermint and red clover. Herbs have side effects so caution should be taken if using them regularly.

Vegetables
Beets supply an amino acid called betaine, according to MedHelp.com, which produces an antidepressant effect in the brain and aids in the regulation and production of neurotransmitters like dopamine. Artichokes and avocados are also great to include in a diet for helping to raise dopamine levels.

If you are further interested in taking another look into Dopamine. The mammalian brain, or limbic system, is largely the same in all mammals. It has been around for well over 100,000,000 years, lurking right beneath your large, rational neo-cortex. Rats, apes and humans use the same neurochemicals to operate the same functions in this part of the brain. Scientists aren't studying rodent brains to help them with their addictions and erections!
Thanks to your limbic system, you cannot will your feelings, emotions, falling in love, or staying in love, anymore than you can will your heart to beat, or yourself to digest a meal or sleep.
Recently, scientists have begun to unravel the neurochemistry of lust, attachment and falling in love. Falling in love involves simultaneous activation and deactivation of discrete parts of the limbic system. For every biological event in your body, there is a biological cause. In this case, the cause is neurochemicals—and the pathways they turn on and off. The central neurochemical player behind falling in—and out—of love is dopamine. Dopamine is the principal neurochemical that activates your reward circuitry. Your reward circuitry drives nearly all of your behaviors. In other words, most all roads lead to Rome, or to the reward circuitry so you can assess things as "good, bad, or indifferent."
At its most basic, this circuit is activated when you engage in activities that further your survival, or the continuation of your genes. Whether it’s sex, eating, taking risks, achieving goals, or drinking water, all increase dopamine, and dopamine turns on your reward circuitry. You can think of dopamine as the "I’ve got to have it" neurochemical, whatever "it" is. It’s the "craving" signal.
The more dopamine you release and the more your reward circuit is activated, the more "reward" you experience. A good example is food. We get a much bigger blast of dopamine eating high-calorie foods than we do low-calorie foods. It’s why we choose chocolate cake over Brussels sprouts. Our reward circuit is programmed so that "calories equal survival." You’re not actually craving ice cream, or a winning lotto ticket, or even a romp in the sack. You’re craving the dopamine that is released with these activities. Dopamine is your major motivation, not the item or activity.
Addiction mechanisms are complex. Yet the one aspect they share is dopamine. All addictive substances and activities increase dopamine. Porn, accumulating money, gaining power over others, gambling, compulsive shopping, video games…if something really boosts your dopamine, then it’s potentially addictive for you. Why did Martha Stewart risk everything for more money? She got a thrill from a stock market gamble. She didn’t need the money; she needed the dopamine.
Addictiive highs mimic the good feelings of the basic activities for which we're actually wired...by hijacking our wiring. Out of thousands of chemicals, these few substances (alcohol, cocaine, etc.) jack up dopamine. We can also hijack it with extremely stimulating versions of natural behaviors: casinos with hot hostesses, novel porn at every click, tasty junk food filled with fat and sugar, and so forth.
Do not get the idea that dopamine is bad. There's no such thing as a bad neurochemical or hormone, although both can be problems when out of balance. Dopamine is absolutely necessary for your decision-making, happiness, and survival. Researchers placed electrodes in rats’ reward centers to stimulate them, much as dopamine does. The rats could then press a lever to stimulate the reward center. That’s all those rats did. They ignored food, receptive females and their own pups, if female. They just sat there pressing the lever over and over, wasting away…not unlike crack addicts. In other experiments, scientists blocked dopamine so the reward center could not be stimulated. What happened? The rats just sat there, again—ignoring food, receptive mates, and the opportunity to explore their environment.